Showing posts with label Epigallocatechin gallate. Show all posts
Showing posts with label Epigallocatechin gallate. Show all posts

Thursday, February 4, 2010

Green tea might help to treat Uterine Fibroids....

In continuation of my update on green tea   (pic : source : ).......  

We have seen many research groups  trying to explore the  usefulness of  green tea for reduction in heart disease (bad cholesterol),  increase in metabolic rate (fat oxidization) prevention  of Alzheimer’s or Parkinson’s diseases, lowering incidence of cancers and  weight reduction.
 Now researchers from Meharry Medical College in Nashville, Tenn lead  Dr. Ayman Al-Hendy ,   have found that green tea extract shows promise as a treatment for uterine fibroids. The key ingredient responsible for this activity is  "epigallocatechin gallate (EGCG)". The researchers investigated  the effect of epigallocatechin gallate  on rat leiomyoma (ELT3) cells in vitro and in a nude mice model. ELT3 cells were treated with various concentrations of EGCG. Cell proliferation, proliferation cell nuclear antigen (PCNA), and cyclin-dependent kinase 4 (Cdk4) protein levels were evaluated. As per the claim by the researchers, EGCG significantly decreased PCNA and Cdk4 protein levels. The authotrs conclude that EGCG effectively inhibits proliferation and induces apoptosis in rat ELT3 uterine leiomyoma cells in vitro and in vivo.

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Monday, December 7, 2009

Combination of EGCG & DAPH-12 - a treatment for brain disorders ?

Amyloid plaques are tightly packed sheets of proteins that infiltrate the brain. These plaques, which are stable and seemingly impenetrable, fill nerve cells or wrap around brain tissues and eventually (as in the case of Alzheimer's) suffocate vital neurons or brain cells, causing loss of memory, language, motor function and eventually premature death.

To date, researchers have had no success in destroying plaques in the human brain and only minimal success in the laboratory. One reason for these difficulties in finding compounds that can dissolve amyloids is their immense stability and their complex composition.

Yet, Dr. Duennwald ( Boston Biomedical Research Institute , BBRI) and co workers from Pennsylvania School of Medicine, experienced success in previous studies when he exposed amyloids in living yeast cells to EGCG (see the above structure). Furthermore, he and his collaborators also found before that DAPH-12, (see below structure) too, inhibits amyloid production in yeast.

About EGCG :
Epigallocatechin gallate, also known as Epigallocatechin 3-gallate, is the ester of epigallocatechin and gallic acid and a type of catechin. EGCG is the most abundant catechin in most notably tea, among other plants, and is also a potent antioxidant and that may have therapeutic properties for many disorders including cancer. It is found in green tea, but not black tea, as EGCG is converted into thearubigins in black teas. EGCG can be found in many supplements.

These findings are significant because it is the first time a combination of specific chemicals (EGCG & DAPH-12) has successfully destroyed diverse forms of amyloids at the same time.

Though the detailed mechanism is still to be established, its a good achievement and hope this combinatorial therapy will help those sufferings from Alzheimer's and other degenerative diseases (Huntington's, and Parkinson's) in the days to come.....

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