Sunday, February 8, 2009

Vigabatrin to treat infantile spasm ?

We know that Vigabatrin, is an antiepiletic agent. Epilepsy can be repressed if the serum level of {gamma}-Aminobutyric Acid, (GABA) is increased. Vigabatrin is an irreversible inhibitor of GABA transminase (GABA-T), the enzyme responsible for the catabolism of GABA. The mechanism of the Vigabatrin, is attributed to an irreversible inhibition of GABA-T and consequently increased level of GABA.

Its use, has been limited in many countries because it has been shown to cause a permanent narrowing of visual fields in approximately 40 percent of adults who have been exposed at school age or later.

However a new study has showed this drug can be used to treat infantile spasm.

The findings show that the risk of permanent visual field defects caused by VGB may be lower for treatments in infants than in adults. The cumulative VGB doses and treatment durations in the study were, on average, lower than in previous studies, which correspond to the much younger age and weight of the tested patients. Hope these results may encourage doctors to use vigabatrin to treat infantile spasms as the risk for visual field damage may be relatively low in many children compared to the risks caused by continuous seizures. Congarts Dr. Eija Gaily and co workers.....

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