Sunday, February 1, 2009

Nano-insulin pill ?

In my earlier blog, I wrote about the use of nanoparticles in the field of Pharmaceutical will happen in the near future. But I didn’t expect it to happen so fast. Thanks to Dr.Chandra Sharma (of Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala, India) for his success in achieving this fete so fast. Its something interesting, becoz, he has chosen the field of diabetic treatment. I think this research, will be a boon to the number of insulin dependent patients (40% of 135 million people) once established in human trials. Hope this research, will lead to other drugs with nanoparticle coating for more efficacy and reduced side effects.

The minute nanoparticles are smaller than 100 nanometres across and attract water on the inside and are water-repelling on the outside - when they reach the bloodstream they break down in response to the pH of blood and then release the insulin.

The animal experiments demonstrated that the nanoparticles enter the bloodstream and end up in organs such as the liver and kidney and in diabetic pigs showed the pill containing the nanoparticles led to control of blood glucose after eating. Though the results are encouraging in the animal models, have to be established in human beings and also most importantly the impact of nanoparticles in human beings has to be studied thoroughly, so that a concrete and conclusive evidence will happen in the coming days. I hope this will research will open flood gate for other drugs with nanoparticles coating. More....


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