Friday, May 15, 2026

Probing a paradoxical drug response for irregular heartbeat



                                                                               Mexiletine
https://go.drugbank.com/drugs/DB00379
https://en.wikipedia.org/wiki/Mexiletine

Irregular heartbeat, or arrhythmia, can be treated with various procedures or medication, but not all medications work for all patients. In fact, one arrhythmia medication can actually cause arrhythmia in people with a common genetic variant. This problem creates a need for personalized medicine to provide patients with the most beneficial outcome, according to new research from WashU

Jon Silva, a professor of biomedical engineering in the McKelvey School of Engineering at Washington University in St. Louis, and Martina Marras, a doctoral student in his lab, made their discovery by screening four genetic variants to see if any of them altered the effectiveness of the drug mexiletine. The work is published in The Journal of Precision Medicine: Health and Disease.


https://medicalxpress.com/news/2026-01-stem-cell-expert-qa-pathways.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal