Monday, August 15, 2011

Two Randomized Trials of Linaclotide for Chronic Constipation

We know that, Linaclotide (BELOW STRUCTURE) is an experimental peptide agonist of guanylate cyclase 2C that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation. The drug was developed by Ironwood Pharmaceuticals, based in Cambridge, Massachusetts. 

 Now researchers lead by, Dr. Anthony J. Lembo, an associate professor of medicine at Harvard Medical School and director of the GI Motility Center at Beth Israel Deaconess Medical Center in Boston, have come up with interesting claim  that "people who received the drug had improvement in symptoms, and the treatment was generally well-tolerated". 

Researchers conclude that, linaclotide significantly reduced bowel and abdominal symptoms in patients with chronic constipation (2 trials). Additional studies are needed to evaluate the potential long-term risks and benefits of linaclotide in chronic constipation...

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