Sunday, January 11, 2009

New Benzothiazepine test to catch sports cheats ?

Though there are many tests for drugs (performance enhancers) for the sportpersons, they will try to use the drugs (wherein there are no tests to prove them guilty). Thanks to German research team who have come up with a new test. I am sure this test will try to combat the 'emerging drugs' and bring a sactity to the sport world.

The test detects a core chemical structure belonging to a class of compounds called benzothiazepines. These compounds stabilise protein channels that would otherwise "leak" calcium from muscle cells during strenuous exercise. Calcium is needed for muscle contraction and this "leaking" effect weakens the contractions and is a causal factor in muscle fatigue.

JTV-519 and S-107, benzothiazepines currently in development for the treatment of heart abnormalities, are known to increase endurance in mice. Although they have not yet entered human clinical trials, both can be detected using the test.

As soon as these drugs enter human clinical trials, there is a huge potential for them to be m isused in sports. This preventive research lets us prepare before these compounds are officially launched, says Mario Thevis, (lot of work done by his group in the spectroscopy field) Director of the Center for Preventive Doping Research at the German Sport University of Cologne, Germany, who led the research. The advantage of high resolution mass spectrometry, JTV-519 and S-107 can be detected in spiked urine at concentrations as low as 0.1 nanograms/ml. And hope they will try to achieve the detailed study of the metabolites also, which will further substantaite the evidence...More...

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