Sunday, January 11, 2009

Clioquinol as anti-aging agent?

Clioquinol (5-Chloro-7-iodo-8-hydroxyquinoline), an 80-year old drug once used to treat diarrhea and other gastrointestinal disorders - can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases, something interesting and a serendipity again to the kitty of so many drugs...And the authors claims that Clioquinol is a very powerful inhibitor of clock-1, because clock-1 affects longevity in invertebrates and mice and hence can be used to treat the three age-dependent neurodegenerative diseases. Though detailed investigation is essential and one need to explain why, the drug was withdrawn from the market after being blamed for a devastating outbreak of subacute myelo-optic neuropathy (SMON) in Japan in the 1960s. Hope some solid conclusion will be arrived in the near future..


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