Thursday, February 2, 2012

Study shows grape seed extract kills head and neck squamous cell carcinoma cells

A study by researchers lead by Dr.Rajesh Agarwal,  shows that in both cell lines and mouse models, grape seed extract (GSE) kills head and neck squamous cell carcinoma cells, while leaving healthy cells unharmed. "It's a rather dramatic effect," says Rajesh Agarwal, PhD, investigator at the University of Colorado Cancer Center and professor at the Skaggs School of Pharmaceutical Sciences.

Grape seed extract creates these conditions that are unfavorable to growth. Specifically, the paper shows that grape seed extract both damages cancer cells' DNA (via increased reactive oxygen species) and stops the pathways that allow repair (as seen by decreased levels of the DNA repair molecules Brca1 and Rad51 and DNA repair foci).

 "Yet we saw absolutely no toxicity to the mice, themselves," Agarwal says.
Interestingly,  the grape seed extract killed the cancer cells but not the healthy cells. As per the lead reseacher,  the  cancer cells have a lot of defective pathways and they are very vulnerable  and one can  target those pathways. The same is not true of healthy cells," adds Agarwal.

The Agarwal Lab hopes to move in the direction of clinical trials of grape seed extract, potentially as an addition to second-line therapies that target head and neck squamous cell carcinoma that has failed a first treatment.

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