tag:blogger.com,1999:blog-6520560265126950473.post5965908435183949907..comments2024-02-28T22:44:30.969+05:30Comments on Med-Chemist: 7,8-Dihydroxyflavone (a selective TrkB agonist) as new class of brain protecting drugs ?https://www.med-chemist.comhttp://www.blogger.com/profile/00786134978315983333noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-6520560265126950473.post-43420305629162815632010-02-12T03:49:06.924+05:302010-02-12T03:49:06.924+05:30You're right, this paper is a big deal - so fa...You're right, this paper is a big deal - so far the only TrkB agonists have been partial agonists, and even then they're generally peptides or peptide mimetics, and none of them have really made it past animal testing. You can imagine that you'd need a fairly longer molecule, probably a dimer, and definitely one like a peptide, to pull the "receiver" dishes together, so it's so fascinating that they were able to use such a small molecule sans nitrogens to achieve this. I'm going to check out the paper to see how exactly they're sure the molecule is doing it - it's not upregulating BDNF?Thttps://www.blogger.com/profile/15948484214663367206noreply@blogger.com