Saturday, November 17, 2012

Cinacalcet failure raises trial conduct issues.....

We know that, Cinacalcet (see above structure) is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. It is sold by Amgen under the trade name Sensipar in North America and Australia and as Mimpara in Europe. Cinacalcet is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels), a consequence of having end-stage renal disease.   Cinacalcet is also indicated for the treatment of hypercalcemia in patients with parathyroid carcinoma. 

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