Sunday, May 20, 2012

Black pepper compound fights fat

We know the that, black pepper has many medicinal benefits, like  curing illness such as constipation, diarrhea, earache, gangrene, heart disease, hernia, hoarseness, indigestion, insect bites, insomnia, joint pain, liver problems, lung disease, oral abscesses, sunburn, tooth decay, and toothaches. Now Korean researchers report that piperine (see structure below), a pungent compound found in black pepper (Piper nigrum), helps block the formation of new fat cells, a process known as adipogenesis.

"Adipogenesis is a well-organized process regulated by adipogenic transcription factors, such as peroxisome proliferator-activated receptor-gamma (PPAR-gamma), sterol regulatory element binding protein (SREBP) family, and CCAAT-enhancer binding protein (C/EBP) family," the authors write in their introduction. "Of these factors, PPAR-gamma has been focused on its role in adipocyte differentiation. In addition to being induced during adipogenesis, it is both necessary and sufficient for the process."

In addition to other benefits such as enhancing nutrient absorption in the digestive tract, black pepper has been found to reduce blood glucose and lipids. In the current study, Soo-Jong Um, Ji-Cheon Jeong and colleagues tested the effects of black pepper extract and piperine on cultured preadipocytes and found that both inhibited the cells differentiation into mature fat cells. Expression of the genes for PPAR-gamma, SREBP-1c and C/EBP-beta were all found to be decreased, as was the binding of PPAR-gamma to a coactivator known as CREB-binding protein following the administration of either treatment. Piperine was also shown to repress LXR-alpha, another transcriptional factor that is involved in the induction of adipogenesis as well as the synthesis of cholesterol and fatty acids.

"Taken together, our findings suggest that piperine, a major component of black pepper, inhibits fat cell differentiation by down-regulating the transcriptional activity of PPAR-gamma (and LXR-alpha) and suppressing the expression of PPAR-gamma (and LXR-alpha), thus leading to its potential use in the treatment of obesity-related diseases," the authors conclude.

Ref : http://pubs.acs.org/doi/abs/10.1021/jf204514a?prevSearch=%255BContrib%253A%2BSoo-Jong%2BUm%255D&searchHistoryKey=

3 comments:

Musadhique Kottapramban said...

thanks dear for your post.
Actually I am indian and I am here in German. I have nothing but pepper to add in any food here. I was wondering if pepper has this much scinetific benifit, then I would be nappy to have pepper more and more..!
anyway is there any peoblem to have exess pepper? I think no..!!

rawtherspices said...

SA Rawther Spices is the largest processor and exporter of black pepper and dry ginger in India, apart from having a good track record in the international trade of coffee, turmeric, cloves, chillies, nutmeg and other products.

BLACK PEPPER
Botanical names: Piper nigrum
Family name: Piperaceae.
Black pepper is considered the `King of Spices` as judged from the volume of international trade, being the highest among all the spices known. Black pepper is produced from the still-green unripe berries of the pepper plant. Black pepper constitutes an important component of culinary seasoning of universal use and an essential ingredient of numerous foodstuffs. It has a number of medicinal virtues.


FOR MORE DETAILS VISIT : http://rawther.co.in/

dr.umesh l said...

Possible side effects of pepper are

1. may cause an increase in parietal secretion (of hydrochloric acid - the acid abovementioned as an aid to digestion) and pepsin secretion and a loss in potassium.

2. chance of mucosal mircrobleeding and even gastric bleeding