Saturday, March 31, 2012

Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer — NEJM

We know that Olaparibis a experimental chemotherapeutic agentdeveloped by KuDOS Pharmaceuticals and later by Astra Zeneca, that failed to progress through clinical trials to approval. It is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which includes many ovarian, breast and prostate  


Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer — NEJM



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